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Injectable Vitamin B6 250 mg/5 ml

14.99EUR

The family of B vitamins, which are also known as B complex vitamins, plays an important role in converting food into energy and helping the body metabolize fats and proteins.
 
The B vitamins are also important for healthy hair, skin, liver, and eyes.

Vitamin B6, or pyridoxine, is one in this group of eight vitamins.
 
Vitamin B6 it is important for cardiovascular, digestive, immune, muscular, and nervous system function. 
 
The B6 vitamin is needed for proper brain development and function and to make the hormones serotonin and norepinephrine, which affect mood.
 
Vitamin B6 also helps the body make melatonin, which is important in helping regulate your internal clock.
 
All B vitamins are water-soluble, which means that they dissolve in the body’s fluids, and any unneeded amounts are excreted in the urine.
 
Sources of vitamin B6 as well as the other B vitamins every day.

Composition:

5 ml solution for injection (1 ampoule) contains 250 mg pyridoxine hydrochloride and excipients: water for injections.

Therapeutic indications:

 Vitamine B6 250 mg/5 ml is indicated for the treatment or prophylaxis of conditions caused by severe pyridoxine deficiency when oral administration is not possible:

- sideroblastic anemia;

- neurological disorders;

- seborrheic dermatitis,

 

as well as in the following pathological situations:

-alcoholism;

- hereditary metabolic disorders in amino acid metabolism (homocysteinuria, primary type I hyperoxaluria).

 

Pyridoxine is also used to prevent drug toxic neuropathy associated with isoniazid treatment.

 

 

Contraindications:

Hypersensitivity to pyridoxine or to any of the excipients.

Treatment with levodopa in the absence of association of an impact decarboxylase inhibitor.

Precautions:

It is recommended that treatment with pyridoxine (vitamin B6) should not be abruptly discontinued.

Caution and dose adjustment are recommended when using other medicines containing vitamin B6.

Interactions:

In the combination treatment with levodopa, pyridoxine favors peripheral decarboxylation of levodopa, reducing its efficacy. This interaction does not occur, however, if levodopa is associated with a decarboxylase inhibitor.

Certain drugs - isoniazid, cicloserine, hydralazine, penicillamine - given for a long time, antagonize vitamin B6 and cause neurological disorders. Oral contraceptives may also cause B6 hypopinaminosis phenotypes, usually minor

Special warnings:

Patients with Parkinson's disease treated with levodopa can safely associate vitamin B6 only if they use a preparation containing both levodopa and an impact carboxamide inhibitor (carbidopa).

For patients requiring treatment with isoniazid, it is recommended that vitamin B6 is first associated with isoniazid-induced polyneuropathy prophylaxis.

Pregnancy and breast-feeding

Due to the lack of sufficient data, it is advisable to avoid the use of  Vitamine B6 250 mg/5 ml during pregnancy.

Vitamin B6 passes into breast milk, therefore avoiding  Vitamine B6 250 mg/5 ml during breast-feeding.

Effects on ability to drive or use machines

The usual therapeutic doses of vitamin B6 do not affect the ability to drive or use machines. In cases of prolonged long-term doses, sensory and sleepiness neuropathy, incompatible with activities requiring precision or attention, have been reported.

Doses and administration:

 Vitamine B6 250 mg/5 ml is administered intramuscularly or intravenously.

The treatment will be individualized and administered under medical supervision.

Adults

The recommended therapeutic dose is 50 mg - 250 mg pyridoxine (vitamin B6) (1  Vitamine B6 250 mg / 5 ml) daily for 15-20 days. Daily doses of 500 mg vitamin B6 (2  Vitamine B6 250 mg / 5 ml) are indicated for haematological disorders and hereditary metabolic disorders.

The treatment of peripheral neuropathy caused by isoniazid requires the association of vitamin B6 at a dose of 50-250 mg per day.

It is recommended that treatment is not abruptly discontinued in order to avoid the onset of abstinence syndrome.

Side effects:

Vitamin B6 is, as a rule, well tolerated. The administration of high doses of vitamin B6 for a long time may be associated with the occurrence of severe peripheral neuropathy of the sensory type by toxic mechanism. Also, long-term treatment sometimes develops dependence phenomena (eg daily doses of 200 mg vitamin B6 administered for more than 30 days); abrupt withdrawal of vitamin B6 may trigger a withdrawal syndrome.

Overdose:

The occurrence of toxic phenomena (severe peripheral neuropathy of the sensory type) has been reported with high doses (2-6 g daily) for 2-40 months. Such cases require permanent monitoring under hospital conditions.

This product was added to our catalog on Wednesday 11 October, 2017.
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